Activities

Stage I

The preparation of thin gold layers deposited on mica, gold nanoparticles and bithiophene-phenothiazine podands

AI.1 Gold thin layers deposition on mica / Coordinator

AI.2 Preparation of gold nanoparticles / Coordinator

AI.3 Design and synthesis of podands and of their precursors; elaboration of synthesis protocols / Partner 1

AI.4. Characterisation of gold surfaces morphology and of the gold nanoparticles dimension by

AI.5. Numerical simulations of the NMR spectra for podands and bithiophene-phenothiazine macrocycles / Coordinator

AI.6. Identification of podands macrocyclization conditions and of the template effect of various cations by molecular modelling methods / Partener 3

AI.7. Determination if the redox properties of podands by cyclic voltametry / Coordinator

AI.8. Analysis of fluorescence properties for thiophene-phenothiazine podands and the identification of fluorescence vanishing conditions / Partner 2

AI.9. Structural analysis of the podands and of the various bithiophene-phenothiazine macrocycles by NMR and mass spectroscopy / Partener 1

AI.10. Results dissemination/ Coordinator, Partner 1, Partner 2

Stage II

Self-assembled Bidimensional Supramolecular Structures (SBSS) of bithiophene- phenothiazine podands deposited on gold surfaces and gold nanoparticles by mercaptoalkyl units

AII.2. The investigation of the possible effects of self-assembly into SBSS on the spectral features of the bithiophene- phenothiazine podands. IR and UV/VIS spectroscopy / Coordinator

AII.5. Determination of the redox properties of SBSS by cyclic voltametry /Coordinator

AII. 7 The acquisition, installation and testing of the fluorescence spectrometer / Coordinator

AII.8. Investigation of fluorescent properties of SBSS and identification of the fluorescence vanishing conditions by fluorescence spectroscopy / Coordinator

AII.9. Results dissemination / Coordinator

Stage III

SSBS with phenothiazine podands deposited on gold surfaces and nanoparticles via N-mercaptoalkyl units

1. The synthesis of phenothiazine macrocycles with polyethylen glycol chains, and of the phenothiazine and bi-thiophen macrocycles with azobenzen units, respectively, and the design of the synthesis protocol / Partner 1 + Partner E (AIII.1 si AIII.2)

2. The preparation of SBSS by depositing the podands and the macrocycles, respectively, on gold surfaces Au (111) and gold nanoparticles, respectively / Partner 1 (AII.1 si AIII.9)

3. The investigation of the morfology of SBSS and the estimation of their degree of order by atomic force microscopy / Partner 1 (AII.4 si AIII.10)

4. The identification of the geometrical structure of the podands and of the phenothiazine macrocycles, free or attached to gold surfaces, through methods of molecular modeling / Partner 3 (AII.3 si AIII.4)

5. The investigation of the structural changes of SBSS induced by the pH change and/or by complexation with various cations and/or by inducing the photo-isomeristion of the azobenzenic component/ Partner 1 (AII.6 si AIII.12)

6. The determination of the redox properties of the macrocycles and of the SBSS, respectively, by cyclic voltametry / Coordinator (AIII.6 si AIII.11)

7. The numerical simulation of NMR spectra for the synthetized macrocycles and their structural analysis by: mass spectroscopy, NMR, UV-Vis spectroscopy, and X-ray diffraction / Coordinator (AIII.3 si AIII.5)

8. The determination of the strucural changes (cis-trans isomerisation) in macrocycles with azobenzene induced by UV–visible radiation. FT-IR and UV-Vis spectrometry / Coordinator (AIII.7)

9. The determination of the properties of complexation for the synthesized macrocycles and of the structural changes (cis-trans isomerisation) induced by UV – visible radiation in compounds with azobenzene. NMR and ESI-MS spectrometry / Partner 1 + Partner E (AIII.8)

10. The investigation of the fluorescence properties of the macrocycles in solution and, respectively, auto-assembled in SBSS and of the conditions of fluorescence quenching by : fluorescence spectroscopy / Coordinator; Fluorescence microscopy/ Partner 2 (AIII.13)

11. Results dissemination/ Coordinator, Partner 1, Partner 2, Partner 3 (AIII. 14)

Stage IV

1. The acquisition, the installation and the testing of an Isothermal Titration Calorimeter (ITC) / Coordinator (AI.10)

2. The investigation of the geometrical structure of the phenothiazine macrocycles through molecular modeling methods / Partner 3, Coordinator (AIV.3 si AV.2)

3. Preparation of the phenothiazine macrocycles with two mercaptomethyl units and of their intermediaries (podands) / Partner 1, Partner E (AIV.1, AIV.2, AIV.4, AIV.9, AV.1, AV.3, AV.4)

4. The physico-chemical and structural analysis of the phenothiazine macrocycles compounds and the investigation of the induced changes by complexation with various cations / Coordinator, Partner 2 (AIV.2, AIV.4, AIV.5, AIV.9, AIV.10, si AV.3-5)

5. The preparation of SBSS by depositing the phenothiazine macrocycles compunds on gold surfaces (111) and gold nanoparticles, respectively / Partner 1 (AIV.6.; AV.6)

6. The investigation of the morphology and of the physico-chemical and structural properties of SBSS / Coordinator, Partner 1 (AIV.6.; AV.6)

7. Results dissemination / Coordinator, Partner 1, Partner 2, Partner 3 (AIV.11)

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