{"id":12,"date":"2024-04-16T08:57:59","date_gmt":"2024-04-16T08:57:59","guid":{"rendered":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/?page_id=12"},"modified":"2026-03-12T10:07:41","modified_gmt":"2026-03-12T10:07:41","slug":"home","status":"publish","type":"page","link":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” background_color=”#0C71C3″ custom_padding=”96px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_font=”|600|||||||” header_text_align=”center” header_text_color=”#FFFFFF” header_font_size=”36px” header_line_height=”2em” global_colors_info=”{}”]<\/p>\n

Development of New Polymeric Antibacterial Materials<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”aboutproject” _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” header_3_text_align=”left” header_3_text_color=”#0088cc” header_3_font_size=”26px” global_colors_info=”{}”]<\/p>\n

About project
<\/strong><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_3_text_color=”#0088cc” header_3_font_size=”26px” global_colors_info=”{}”]<\/p>\n

Beneficiary:<\/span><\/strong> National Institute for Researrch and Development of Isotopic and Molecular Technologies<\/p>\n

Project Code:<\/strong><\/span> CF 108_31.07.23<\/p>\n

Contract no.:<\/strong><\/span> 760242 \/ 28.12.2023<\/p>\n

Competition:<\/strong><\/span> PNRR-III-C9-2022\u2013I8<\/p>\n

Director\/Project Leader:<\/span> Dr. Anzarul Khan
<\/strong><\/p>\n

Project budget:<\/span><\/strong> 6,000,000 RON<\/p>\n

Project period:<\/span>\u00a0<\/strong>01.01.2024 \u2013 30.06.2026<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”summary” _builder_version=”4.20.4″ _module_preset=”default” background_color=”#0C71C3″ global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_3_font_size=”30px” custom_padding=”2px|||||” global_colors_info=”{}”]<\/p>\n

Project Summary
<\/strong><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”2em” global_colors_info=”{}”]<\/p>\n

For most of the past century, positively charged quaternary alkyl ammonium salts have been used as antibacterial agents. Their mechanism of action involves initial attraction and adsorption onto the negatively charged bacterial cell membrane through electrostatic interactions. The alkyl substituents then enter the cell membrane thereby weakening and disrupting it through hydrophobic interactions. In this way, the membrane selectivity for permeation is lost thus allowing the cationic salts to enter the cell. A net result of the compromised cell wall is the leaking of cytoplasmic constituents and cell death. However, extensive use of the quaternary ammonium salts has led bacteria to develop resistance against such materials. Therefore, the identification of new cationic moieties for antibacterial purposes is a high-priority area of research. World Health Organization (WHO) has recognized that antibiotic resistance is one of the biggest threats to global health today. Thus, in this project, we strive to develop novel non-ammonium antibacterial materials.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”objectives” _builder_version=”4.24.3″ _module_preset=”default” background_color=”#08418c” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_3_font_size=”30px” custom_padding=”2px|||||” global_colors_info=”{}”]<\/p>\n

Project Objectives
<\/strong><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”2em” global_colors_info=”{}”]<\/p>\n

1<\/strong>) Synthesis and characterization of a new family of polymeric antibacterial materials<\/p>\n

2<\/strong>) Study of their toxicity (hemolytic) properties against mammalian red blood cells<\/p>\n

3<\/strong>) Study of their antibacterial properties against E. coli<\/em>, S. aureus<\/em>, and M. Smegmatis<\/em><\/p>\n

4<\/strong>) Study of their antibacterial machanism through membrane permeabilization assays<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”team” _builder_version=”4.20.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.20.4″ _module_preset=”default” header_3_text_align=”left” header_3_text_color=”#0088cc” header_3_font_size=”26px” global_colors_info=”{}”]<\/p>\n

Research Team<\/strong><\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Anzarul Khan” position=”Principal Investigator, R3, Established Researcher” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Diana Laz\u0103r” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-lazar-mihaela-diana\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R4, Leading Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Lucian Barbu” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-barbu-lucian\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R3, Established Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Gabriela Bl\u0103ni\u021b\u0103” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-blanita-gabriela\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R3, Established Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Adrian P\u00eern\u0103u” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-pirnau-adrian\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R3, Established Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Florina Pog\u0103cean” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-pogacean-florina\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R3, Established Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Monica Dan” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/dr-dan-monica-alexandrina-diana\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R2, Recognised Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Eng. Oana Grad” position=”R2, Recognised Researcher” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/dr-grad-oana\/” link_option_url_new_window=”on” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Maria Suciu” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”http:\/\/en.itim-cj.ro\/portfolio\/dr-suciu-maria\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”R2, Recognised Researcher” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Maricel Boc\u0103neal\u0103” position=”R1, First Stage Researcher” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/bocaneala-maricel\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Rajashekar Narra ” position=”R1, First Stage Researcher, post-doc” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Dr. Amit Sharma” position=”R1, First Stage Researcher, post-doc” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/sharma-amit\/” sticky_enabled=”0″ link_option_url_new_window=”on”][\/et_pb_team_member][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Eng. Drago\u0219 Cosma” _builder_version=”4.27.6″ _module_preset=”default” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/ing-cosma-dragos-viorel\/” link_option_url_new_window=”on” hover_enabled=”0″ global_colors_info=”{}” position=”ACS, Scientific Research Assistant” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Radu Onija” position=”ACS, Scientific Research Assistant, PhD student” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/onija-radu-ioan\/” link_option_url_new_window=”on” sticky_enabled=”0″][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Oltean Sorin” _builder_version=”4.27.6″ _module_preset=”default” hover_enabled=”0″ global_colors_info=”{}” link_option_url=”https:\/\/en.itim-cj.ro\/portfolio\/oltean-sorin-teodor\/” link_option_url_new_window=”on” sticky_enabled=”0″ position=”TS, Senior Technician”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”results” _builder_version=”4.20.4″ _module_preset=”default” background_color=”#0C71C3″ global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.23.1″ _module_preset=”default” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_3_font_size=”30px” global_colors_info=”{}”]<\/p>\n

Results<\/strong><\/h3>\n

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ISI Publications<\/strong><\/p>\n

    \n
  1. Anzar Khan, Cleavable azobenzene linkers for the design of stimuli-responsive materials<\/strong><\/a><\/span>, Chem. Commun. 60 (2024) 6591\u20136602<\/li>\n
  2. Anzar Khan, Photopolymerization using Thiol-Epoxy \u2018Click\u2019 Reaction: Anionic Curing through Photolatent Superbases<\/span><\/a><\/strong>, ACS Polymers Au, 5 (3) (2025) 174-183<\/li>\n
  3. Anzar Khan, Thiol-epoxy \u2018click\u2019 reaction in polymer synthesis<\/span><\/a><\/strong>, Progress in Polymer Science, 169 (2025) 102022<\/li>\n<\/ol>\n

    \u00a0Presentations<\/strong><\/p>\n

      \n
    1. Anzar Khan, Design of activatable and charged polymers targeted at Bio-relevant applications<\/strong>, ACS Spring Meeting 2025, Session: Global Virtual Symposium: Polymers for Biomedical Applications, Martie 23-27, 2025, (San Diego, CA). – The paper received the Best Flash Presentation Award<\/strong><\/em><\/li>\n
    2. Anzar Khan, Synthesis of Polymers containing sulfonium and selenium cations<\/strong>, invited presentation at School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University Singapore
      <\/strong><\/li>\n<\/ol>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_id=”contact” _builder_version=”4.24.3″ _module_preset=”default” background_color=”#08418c” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” text_text_color=”#FFFFFF” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_3_font_size=”26px” global_colors_info=”{}”]<\/p>\n

      Contact<\/strong><\/h3>\n

      [\/et_pb_text][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” text_text_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

      \"\"National Institute for Research and Development of Isotopic and Molecular Technologies – INCDTIM Cluj-Napoca<\/p>\n

      67-103 Donat Street, P.O. Box 700,
      RO-400293 Cluj-Napoca 5, Romania<\/p>\n

      \"\"+40 264 584037<\/p>\n

      \"\"itim@itim-cj.ro<\/p>\n

      [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-content\/uploads\/2025\/04\/locatie.jpg” title_text=”locatie” _builder_version=”4.24.3″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” custom_padding=”5px||7px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” text_font=”Poppins||||||||” global_colors_info=”{}”]<\/p>\n

      \u201cCon\u021binutul acestui material nu reprezint\u0103 \u00een mod obligatoriu pozi\u021bia oficial\u0103 a Uniunii Europene sau a Guvernului Rom\u00e2niei\u201d<\/span><\/p>\n

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      \u201ePNRR. Finan\u021bat de Uniunea European\u0103 \u2013 Urm\u0103toareaGenera\u021bieUE\u201d<\/span><\/p>\n

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      https:\/\/mfe.gov.ro\/pnrr\/<\/a><\/span><\/p>\n

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      https:\/\/www.facebook.com\/PNRROficial\/<\/a><\/span><\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

      Development of New Polymeric Antibacterial MaterialsAbout projectBeneficiary: National Institute for Researrch and Development of Isotopic and Molecular Technologies Project Code: CF 108_31.07.23 Contract no.: 760242 \/ 28.12.2023 Competition: PNRR-III-C9-2022\u2013I8 Director\/Project Leader: Dr. Anzarul Khan Project budget: 6,000,000 RON Project period:\u00a001.01.2024 \u2013 30.06.2026Project SummaryFor most of the past century, positively charged quaternary alkyl ammonium salts have […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-12","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/pages\/12","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":19,"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":72,"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/pages\/12\/revisions\/72"}],"wp:attachment":[{"href":"http:\/\/www.itim-cj.ro\/pnrr\/cf108\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}