Funcţia în cadrul Proiectului: DIRECTOR DE PROIECT

1. Nume:                                                   LIEBSCHER            

2. Prenume:                                             JÜRGEN

3. Data şi locul naşterii:                     October 4, 1945, Freital, Germany

4. Cetăţenie:                                            germana

5. Stare civilă:                                        casatorit

6. Studii:

Instituţia	Perioada	Grade sau diplome obţinute
Universitatea Tehnica Drezda, Germania	1964-1969	Diploma de Licenta
Universitatea Tehnica Drezda, Germania	1969-1973	Doctor
Universitatea Tehnica Drezda, Germania	1974-1977	Calificare superiora

7. Experienţa profesională:

Instituţia	Perioada	Funcţia	Descriere
Universitatea Tehnica Dresda, Germania	1969-1978	Asistent, Asistent cercetare	Cerecetare si predare în domeniul chimiei organice (coloranti, sinteza organica, chimia heterociclurilor).
Universitatea Etiopia, Addis Ababa	1979-1982	Profesor asociat	Cerecetare si predare în domeniul chimiei organice (sinteza organica, chimia heterociclurilor, produsi naturali).
Universitatea Humboldt Berlin	1982-1992	Conferentiar, conducator a unui grup de cercetare	Predare a chimiei organice, cercetare în domeniul chimiei organice (sinteza, compusi farmacologici, chimia heterociclurilor)
Universitatea Humboldt Berlin	1993- pana în prezent	Profesor, Director al Institutului de Chimie Organica si Chimie Biorganica, Conducator a unui grup de cercetare.	Predare a chimiei organice, cercetare în sinteza, materiale, polimeri, functionalizarea particulelor magnetice, lichide ionice, cataliza si organocataliza, sinteza asimetrica, sinteza compusilor farmacologici, chimie biorganica (acizi nucleici, lipide, aminoacizi, peptide, alcaloizi, carbohidrati), peroxizi organici.

8. Titluri stiintifice: Profesor Doctor, conducator de doctorat

9. Limbi străine cunoscute: engleza

10. Brevete  de invenţii, dacă există  (in total 169):

- RO-A/00401 – (15.07.2008), Preparation of magnetic nanostructures based on polypyrrole functionalized at N-atom by peptides

      - EP 90002395.3 – 2123 – (20.02.2009), Pharmaceutical compositions and their application în treatment of tumor diseases

      - WO 2007/096134 A1 (30. 8. 2007), Lipidated oligonucleotides

       - US 5 684 160 (4. 11. 1997), 3-Aminopyrroles, methods of their synthesis and application as pharmaceuticals

       - DD 299 273 (1992), Procedure for the extraction of silver from aqueous solutions

 

11. Lucrări publicate, dacă există (in total 232):

- M. Loew, J. Kang, L. Dähne, R. Hendus-Altenburger, O. Kaczmarek, J. Liebscher, D. Huster, K. Ludwig, C. Böttcher, A. Herrmann, A. Arbuzova: Controlled Assembly of Vesicle-based Nanocontainers on Layer-by-Layer Particles via DNS Hybridisation“ Small 2009, 5, 320.

- A. Nan, S. Karsten,  I. Craciunescu, R. Turcu, L. Vekas, J. Liebscher: “New shells for magnetic nanoparticles based on polypyrrole functionalized with α-amino acids” ARKIVOC, 2008, 307.

- Z. Yacob, J. Shah, J. Leistner, J. Liebscher: „(S)-Pyrrolidin-2-ylmethyl-1,2,3-triazolium salts Ionic-Liquid-Supported Organocatalysts for Enantioselective Michael Addition to ß-Nitrostyrenes”, Synlett 2008, 2342.

- J. Shah, H. Blumenthal, Z. Yacob, J. Liebscher: „Proline catalyzed asymmetric aldol reactions în guanidine-derived ionic liquids“ Adv. Synth. Catal., 2008, 350, 1267.

-A. Kurz, A. Bunge, A.-K. Windeck, M. Rost, W. Flasche, A. Arbuzova, D. Strohbach, S. Müller, J. Liebscher, D. Huster, A. Herrmann: „Lipid-Anchored Oligonucleotides for Stable Double Helix Formation în Distinct Membrane Domains” Angew.Chem. 2006, 118, 4550.

12. Membru al asociaţiilor profesionale: Societatea Germana de Chimie, Societatea Internationala de Chimia Heterociclurilor (membru în comitetul consultativ), Societatea Liebig, Societatea Profesorilor din Germania.

 

13. Specializări şi calificări: Sinteza organica cu o vasta intindere în diferite domenii si o cuprinzatoare experienta dobandita de-a lungul multor ani, nanobiotehnologie, materiale, chimie bioorganica, cataliza, lichide ionice, sinteza asimetrica.

 

14. Experienţa acumulată (inclusiv managerială) în alte programe/proiecte naţionale/internaţionale:

Programul/Proiectul	Funcţia	Perioada
DFG (Fundatia Germana pentru Cercetare)	Director – în diferite proiecte	Incepand din 1992
INTAS Program (UE)	Referent	1994
DFG (Fundatia Germana pentru Cercetare)	Refrent	Incepand din 2007
Programul pentru Nanobiotehnologie a Ministerului German de cercetare si de Invatamant Superior	Director de proiect	Incepand din 2004
Programul pentru lichide ionice ca medii de reactie innovative a Ministerului German de cercetare si de Invatamant Superior	Director de proiect	Incepand din 2005
Programul prioritar pentru organocataliza, DFG	Director de proiect	Incepand din 2008

15. Lista celor mai importante publicatii/brevete:

- Hu Peng, Soundarapandian Vijayakumar, Cordelia Schiene-Fischer, Hui Li, Jeffrey M. Purkerson, Miroslav Malesevic, Jürgen Liebscher, Qais As-Awqati, George J. Schwartz: „Sectreted Cyclophilin A, a Peptidylprolyl cis-tran Isomerase, Mediates Matrix Assembly of Hensin, a Protein Implicated în Epithelial Differentiation” J. Biol. Chem., 2009, 284, 6465.

- J. Shah, J. Liebscher: „Synthesis of Chiral α-Amino Ester Derived Pentasubstituted Guanidines and Hexasubstituted Guanidinium Salts as Potential Ionic Liquids”, Synthesis, 2008, 917.

- O. Kaczmarek, N. Brodersen, A. Bunge, L. Löser, D. Huster, A. Herrmann, A. Arbuzova, J. Liebscher: „Synthesis of Nucleosides with 2´-Fixed Lipid Anchors and Their Behavior în Phospholipid Membranes”,   Eur. J. Org. Chem.,2008, 1917.

- J. Shah, J. Liebscher: „Synthesis of Chiral α-Amino Ester Derived Pentasubstituted Guanidines and Hexasubstituted Guanidinium Salts as Potential Ionic Liquids”, Synthesis, 2008, 917.

- S. Hanelt, J. Liebscher: „A Novel and Versatile Access to Task-Specific Ionic Liquids Based on 1,2,3-Triazolium Salts”, Synlett, 2008, 1058.

- H.-J. Hamann, A. Bunge, J. Liebscher: „Reaction of Epoxyketones with Hydrogen Peroxide - Ethane-1,1-dihydroperoxid as a Surprisingly Stable Product“, Chemistry Eur. J. 2008, 14, 6849.

- R. Turcu, A. Nan, I. Craciunescu, J. Liebscher, O. Pana, D. Bica, L.Vekas, C. Mijangos: “Comparative study of hybrid nanostructures of polymer-magnetic nanoparticles”, Journal of Optoelectronics and Advanced Materials, vol. 10, No. 9, 2008, 2237.

- A. Nan, I. Craciunescu, R. Turcu, D. Reichert, J. Liebscher: „Synthesis and characterization of new functionalised pyrrole copolymers”, Journal of Optoelectronics and Advanced Materials, 2008, 10, 2265.

- A. Nan, I. Craciunescu, A. Bende, R. Turcu, D. Reichert, J. Liebscher: „Synthesis and Structure Investigation of Functionalized Polypyrrole Copolymers”, Journal of Nanostructured Polymers and Nanocomposites, 2008, 4, 3.

- A. Bunge, A. Kurz, A.-K. Windeck, T. Korte, W. Flasche, J. Liebscher, A. Herrmann, D. Huster: „Lipophilic Oligonucleotides Spontaneously Insert into Lipid Membranes, Bind               Complementary DNA Strands, and Sequester into Lipid Disordered Domains”, Langmuir 2007, 23, 4455.

- M. Sieber, M. Karanik, C. Brandt, C. Blex, M. Podtschaske, F. Erdmann, R. Rost, E. Serfling, J. Liebscher, M. Pätzel, A. Radbruch, G. Fischer, R. Baumgrass: “Inhibition of calcineurin-NFAT signaling by the pyrazolopyrimidine compound NCI3”, Eur. J. Immun. 2007, 37, 2617.

- N. Brodersen, J. Li,O. Kaczmarek, A. Bunge, L. Löser, D. Huster, A. Herrmann, J. Liebscher: “Nucleosides with 5´-Fixed Lipid Groups – Synthesis and Anchoring în Lipid Membranes”, Eur. J. Org. Chem. 2007, 6060.

- V. Karunakaran, T. Senyushkine, G. Saroja, J. Liebscher, N. P. Ernsting: “2-Amino-7-Nitro-Fluorenes în Neat and Mixed Solvents – Optical Band Shapes and Solvatochromism”, J. Phys. Chem. A, 2007, 111, 10944.

- L. Yin, J. Liebscher: ”Carbon-Carbon Coupling Reactions Catalyzed by Heterogeneous Palladium Catalysts”, Chem. Rev. 2007, 107, 133.

- H.-J. Hamann, A. Wlosnewski, T. Greco, J. Liebscher: „Novel Hydroperoxydioxolanes and –dioxanes by Hydroperoxide-Rearrangement and Ozonolysis”, Eur. J. Org. Chem. 2006, 2174.

- H. Faltz, C. Bender, J.Liebscher: “Synthesis of Optically Active Condensed Tetrahydropyridines from a-Amino Esters”, Synthesis 2006, 2907.

- L. Yin, J. Liebscher: “w-Functionalized 3-Alkynylpyrazolo[1,5-a]pyrimidines by Sonogashira Coupling”, Synthesis 2005, 131.

- G. Saroja, Z. Pingzhu, L. Perez-Lustres, N. P. Ernsting, J. Liebscher: „Donor-Acceptor Substituted Fluorenes for Femtosecond Polar Solvation Studies: Synthesis of Alkylated Aminofluorenes by Palladium-Catalyzed    Substitution at Halofluorenes“, J. Org, Chem. 2004, 69, 987.

- W. Flasche, C. Cismas, A. Herrmann, J. Liebscher: „Lipophilic Nucelosides by Sonogashira Coupling”, Synthesis 2004, 2335.

- L. Yin, J. Liebscher: ”Convenient Synthesis of Substituted 3-Vinyl-pyrazolo[1, 5-a] pyrimidines via Heck Cross-coupling Reaction”, Synthesis 2004, 2329.

- H. Faltz, C. Bender, B. Wöhrl, K. Vogel-Bachmayr, U. Hübscher, K. Ramadan, J. Liebscher: “Double-Cyclization of Di(a-hetarylmethyl)amino Esters to Optically Active Bridged N-Heterocycles of HIV Inhibiting Activity”, Eur. J. Org. Chem. 2004, 3484.

- H. A. Scheidt, W. Flasche, C. Cismas, A. Herrmann, J. Liebscher, D. Huster: „Design and Application of Lipophilic Nucleosides as Building Blocks to Obtain Highly Functional Biological Surfaces”, J. Phys. Chem. B 2004, 108, 16279.

-V. Nair, S. M. Nair, S. Mathai, J. Liebscher, B. Ziemer, K. Narsimulu: “The Rh(II) catalyzed reaction of diethyl diazomalonate with thietanes: a facile synthesis of tetrahydrothiphene derivatives via sulfonium ylides”, Tetrahedron Lett. 2004, 45, 5759.

- S. Swaleh, J. Liebscher: "New Strategy for the Synthesis of Iminoglycitols from Amino Acids", J. Org. Chem. 2002, 67, 3184.

- D. Schley, A. Radspieler, G. Christoph, J. Liebscher: "a-Arylation of 2-Arylacetates and Benzofuran-2-one with Tricarbonyl(fluoroarene)­chromium Complexes", Eur. J. Org. Chem. 2002, 369.

- J. Hübner, J. Liebscher, M. Pätzel: “Optically Active Nitroalkenes – Synthesis, Addition Reactions and Transformation into Amino Acids“,Tetrahedron 2002, 58, 10485.

- A. Radspieler, J. Liebscher:"Total Synthesis of Phorbazole C”, Tetrahedron 2001, 57, 4867.

- S. Jin, P. Wessig, J. Liebscher: "Intermolecular and Intramolecular Diels-Alder Cycloadditions of 3-Ylidenepiperazine-2,5-diones and 5-Acyloxy-2(1H)-pyrazinones", J. Org. Chem. 2001, 66, 3984.

- O. Surygina, M. Ehwald, J. Liebscher: "Enantiomerically Pure Dihydroimidazoisoquinolinones by Reaction of Isoquinoline with amino acid fluorides", Tetrahedron Lett. 2000, 41, 5479.

- S. Jin, P. Wessig, J. Liebscher: "Unusual C=C Bond Migration în 3-Ylidene-2,5-piperazindiones", Eur. J. Org. Chem. 2000, 1993.

- J. Liebscher, S. Jin, A. Otto, K. Woydowski: "Synthetic Application of Chiral Pool Derived Heterocycles", J. Heterocycl. Chem. 2000, 37, 509.

 - DE 196 53 355 A1 (25. 6. 1998), New anticonvulsive aminoimidazoles and methods of their synthesis

- US-Pat. 5 414 082 (1995), Procedure for the synthesis of 1-unsubstituted 3-aminopyrroles

Declar pe proprie răspundere că datele prezentate sunt în conformitate cu realitatea.

Data completării:                                                                        

06.05.2010

Curriculum vitae

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