{"id":89,"date":"2023-05-23T09:04:17","date_gmt":"2023-05-23T09:04:17","guid":{"rendered":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/?page_id=89"},"modified":"2023-05-23T10:15:34","modified_gmt":"2023-05-23T10:15:34","slug":"rezumat-proiect","status":"publish","type":"page","link":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/ro\/rezumat-proiect\/","title":{"rendered":"Rezumat proiect"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.21.0″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_direction=”140deg” background_color_gradient_stops=”rgba(40,89,114,0.67) 1%|#291160 100%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#004872″ background_color_gradient_end=”rgba(41,17,96,0.8)” background_image=”https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-content\/uploads\/2023\/05\/banner-site-01.png” min_height=”325px” min_height_tablet=”325px” min_height_phone=”270px” min_height_last_edited=”on|phone” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”60px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”Roboto|500|||||||” header_text_color=”#FFFFFF” header_font_size=”44px” global_colors_info=”{}” theme_builder_area=”post_content”]

Rezumat proiect<\/h1>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” custom_margin=”|auto||414px||”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content” custom_padding=”||0px|||”]

Statinele sunt cel mai frecvent prescrise medicamente pentru sc\u0103derea nivelului de colesterol. Acestea apar\u021bin clasei II a sistemului BCS (Biopharmaceutical Classification System), ceea ce \u00eenseamn\u0103 c\u0103 sunt slab solubile dar penetreaz\u0103 bine membranele biologice. Chiar dac\u0103 \u00een literatur\u0103 sunt raportate \u0219i forme cristaline (polimorfi \u0219i s\u0103ruri) companiile farmaceutice prefer\u0103 s\u0103ruri \u00een stare amorf\u0103 pentru formularea medicamentelor, deoarece solubilitatea formelor cristaline raportate este \u00een general mai mic\u0103 dec\u00e2t cea a de s\u0103rii amorfe. Comparativ cu formul\u0103rile cristaline, formele amorfe au stabilitate redus\u0103 \u0219i creeaz\u0103 probleme \u00een procesul de formulare, datorate \u00een special capacit\u0103\u021bii de amestecare \u0219i a propriet\u0103\u021bilor reologice.<\/p>\n

\u00cen acest context principalul obiectiv al propunerii este de a ob\u021bine forme cristaline – cocristale. Ob\u021binerea de cocristale utiliz\u00e2nd un coformer adecvat ofer\u0103 posibilitatea \u00eembun\u0103t\u0103\u021birii solubilit\u0103\u021bii prin modificarea structurii cristaline.<\/p>\n

Pentru cele dou\u0103 statine selectate (Pravastatin \u0219i Pitavastatin) se vor aplica tehnici avansate de inginerie cristalin\u0103 \u0219i caracterizare structural\u0103. Pentru a cre\u0219te \u0219ansele ob\u021binerii de cocristale farmaceutice vor fi implementate metode de cristalizare \u201chigh-throughput\u201d, \u00een timp ce pentru cre\u0219terea preciziei\/fiabilit\u0103\u021bii \u00een determinarea structurii cristaline, se va utiliza o metodologie relativ recent\u0103, \u0219i anume, cristalografia RMN, care combin\u0103 difrac\u021bia de raze X cu tehnici complementare precum RMN pe solid \u0219i modelare molecular\u0103.<\/p>\n

Dac\u0103 lu\u0103m \u00een considerare c\u0103 brevetul pentru Pravastatin sodiu (pe pia\u021b\u0103 Pravachol) a expirat \u00een 2016, iar brevetul pentru Pitavastatin calciu (pe pia\u021b\u0103 Livalo) va expira \u00een 2021, noile forme solide cristaline ale statinelor vor da posibilitatea companiilor farmaceutice s\u0103 scoat\u0103 pe pia\u021b\u0103 un medicament generic cu propriet\u0103\u021bi farmaceutice \u00eembun\u0103t\u0103\u021bite. Caracterizarea complet\u0103 a noilor forme cristaline va fi diseminat\u0103 \u00een lucr\u0103ri publicate \u00een reviste de specialitate cotate ISI.<\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

Rezumat proiectStatinele sunt cel mai frecvent prescrise medicamente pentru sc\u0103derea nivelului de colesterol. Acestea apar\u021bin clasei II a sistemului BCS (Biopharmaceutical Classification System), ceea ce \u00eenseamn\u0103 c\u0103 sunt slab solubile dar penetreaz\u0103 bine membranele biologice. Chiar dac\u0103 \u00een literatur\u0103 sunt raportate \u0219i forme cristaline (polimorfi \u0219i s\u0103ruri) companiile farmaceutice prefer\u0103 s\u0103ruri \u00een stare amorf\u0103 pentru […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-89","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/pages\/89","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/comments?post=89"}],"version-history":[{"count":3,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/pages\/89\/revisions"}],"predecessor-version":[{"id":101,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/pages\/89\/revisions\/101"}],"wp:attachment":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/crystatin\/wp-json\/wp\/v2\/media?parent=89"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}