{"id":23,"date":"2023-05-09T11:52:46","date_gmt":"2023-05-09T11:52:46","guid":{"rendered":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/?page_id=23"},"modified":"2023-05-09T12:21:14","modified_gmt":"2023-05-09T12:21:14","slug":"home","status":"publish","type":"page","link":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Hero” _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”0px|||||” bottom_divider_color=”#ededed” bottom_divider_height=”40%” bottom_divider_height_tablet=”” bottom_divider_height_phone=”” bottom_divider_height_last_edited=”on|phone” global_colors_info=”{}”][et_pb_row column_structure=”1_4,3_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ width=”100%” custom_margin=”||||false|false” custom_padding=”||||false|false” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/Sigla-INCDTIM-100.jpg” title_text=”Sigla INCDTIM 100″ url=”http:\/\/ro.itim-cj.ro” url_new_window=”on” align=”right” _builder_version=”4.16″ _module_preset=”default” width=”25%” max_width=”50px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_text_color=”#353535″ text_font_size=”18px” text_line_height=”2.7em” header_font=”||||||||” header_font_size=”40px” header_line_height=”1.4em” custom_margin=”8px||30px||false|false” custom_margin_last_edited=”off|desktop” custom_padding=”|0px||||” header_font_size_tablet=”30px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

National Institute for Research and Development of
Isotopic and Molecular Technologies (INCDTIM)<\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ custom_margin=”-28px|auto||auto||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/logo-1.png” title_text=”logo” show_bottom_space=”off” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_text_color=”#353535″ text_font_size=”18px” text_line_height=”2.5em” header_font=”||||||||” header_font_size=”40px” header_line_height=”2em” max_width=”600px” custom_margin=”||30px|” custom_margin_last_edited=”off|desktop” header_font_size_tablet=”30px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

In silico optimization of CRISPR\/Cas9-Gold nanovehicle design<\/span><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/cas9-01.png” title_text=”cas9-01″ align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ width=”65%” custom_margin=”|||100px|false|false” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”4%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About Us” _builder_version=”4.20.4″ background_enable_color=”off” use_background_color_gradient=”on” background_color_gradient_stops=”#0c71c3 0%|#0c71c3 100%” background_color_gradient_start=”#0c71c3″ background_color_gradient_end=”#0c71c3″ custom_margin=”||||false|false” custom_padding=”50px||1px||false|false” hover_enabled=”0″ global_colors_info=”{}” module_id=”contact” sticky_enabled=”0″][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ custom_margin=”-24px|auto||auto||” custom_padding=”20px|0px|41px|0px|false|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_text_color=”#ffffff” text_font_size=”17px” text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_3_font=”||||||||” header_3_font_size=”24px” header_3_line_height=”1.4em” background_layout=”dark” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”off|desktop” header_3_font_size_tablet=”30px” header_3_font_size_phone=”24px” header_3_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

Project financed by UEFISCDI<\/a><\/span><\/h3>\n

Project Type:<\/strong> Postdoctoral research projects<\/p>\n

Project Code:<\/strong> PN-III-P1-1.1-PD-2019-0292<\/p>\n

Contract No.:<\/strong> PD 37<\/p>\n

Project Duration:<\/strong> 01.09.2020 – 31.08.2022<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” header_font=”||||||||” header_2_font=”||||||||” header_3_font=”||||||||” header_3_font_size=”24px” header_3_line_height=”1.4em” header_4_font=”||||||||” header_4_line_height=”1.4em” background_layout=”dark” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”off|desktop” header_3_font_size_tablet=”30px” header_3_font_size_phone=”24px” header_3_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

Principal Investigator:<\/h3>\n

Dr. Alexandra FARCAS<\/strong><\/p>\n

INCDTIM \u2013 National Institute for Research and Development of Isotopic and Molecular Technologies,
<\/em><\/strong><\/p>\n

Molecular and Biomolecular Physics Department<\/strong><\/em><\/p>\n

67-103 Donat St., Box 700, RO-400293 Cluj-Napoca, Romania<\/p>\n

e-mail: alexandra.farcas@itim-cj.ro<\/p>\n

phone: (+40)264-584037, ext. 177<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About Us” _builder_version=”4.20.4″ background_enable_color=”off” custom_margin=”||||false|false” custom_padding=”50px||50px||false|false” hover_enabled=”0″ global_colors_info=”{}” module_id=”abstract” sticky_enabled=”0″][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#006ef4″ divider_weight=”3px” _builder_version=”4.16″ max_width=”100px” module_alignment=”center” custom_margin=”||0px|” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_text_color=”#0c71c3″ text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_margin=”|||” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Project abstract<\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”2″ padding_top_bottom_link_1=”false” _builder_version=”4.16″ background_color=”#003bde” use_background_color_gradient=”on” background_color_gradient_direction=”160deg” background_color_gradient_stops=”#ffffff 0%|#ffffff 100%” background_color_gradient_start=”#ffffff” background_color_gradient_end=”#ffffff” width=”100%” module_alignment=”center” custom_margin=”|auto|0px|auto|false|false” custom_padding=”|||” border_style_all=”none” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”|300|||||||” text_font_size=”18px” text_orientation=”center” global_colors_info=”{}”]<\/p>\n

CRISPR\/Cas9 gene editing is a novel and versatile technology that correct disease-causing errors in the genomes, with multiple and broad applications in medical, agricultural and pharmaceutical industries. The major obstacle in implementing CRISPR\/Cas9-based therapeutics is to develop nanovehicles that can target genetic mutations in a specific manner. Gold nanoparticles (GNP) functionalized with synthetic oligonucleotides combine the optoelectronic properties of the gold core with the particular properties of oligonucleotides, for instance selectivity and specificity. Furthermore, functionalized GNPs have been previously used in vivo for delivery of CRISPR\/Cas9 to successfully repair gene mutations causing muscular dystrophy. However, prior to clinical applications, safe and efficient CRISPR\/Cas9-Gold-based delivery vehicles should be designed based on a deep understanding of the underlying molecular mechanisms. In this proposal, we intend to computationally optimize such a design in two steps. First, we will optimize the DNA loading on a range of GNP sizes in nanoparticle-oligonucleotide conjugates. In the second stage, we will perform a thorough in silico investigation of GNP-oligonucleotide conjugates complexed with Cas9 ribonucleoprotein as delivery nanovehicles.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”About Us” module_id=”objectives” _builder_version=”4.20.4″ background_enable_color=”off” use_background_color_gradient=”on” background_color_gradient_stops=”#2b87da 0%|#0c71c3 100%” background_color_gradient_end=”#0c71c3″ custom_margin=”||||false|false” custom_padding=”52px||35px||false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_row column_structure=”2_3,1_3″ padding_top_bottom_link_1=”false” module_id=”#objectives” _builder_version=”4.16″ background_enable_color=”off” background_color_gradient_direction=”160deg” background_enable_image=”off” background_size=”initial” width=”100%” module_alignment=”center” custom_margin=”-26px|auto|-3px|auto|false|false” custom_padding=”|||” border_radii=”on|10px|10px|10px|10px” border_style_all=”none” border_width_bottom=”14px” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_text_color=”#0c71c3″ text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_margin=”|||” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Objectives<\/span><\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”|300|||||||” text_font_size=”20px” text_orientation=”center” background_layout=”dark” global_colors_info=”{}”]<\/p>\n

The specific objectives of the project are:<\/p>\n

O1<\/strong> Optimization of DNA loading on a range of GNP sizes in nanoparticle-oligonucleotide conjugates.<\/p>\n

O2<\/strong> In silico investigation of GNP-oligonucleotide conjugates complexed with Cas9 ribonucleoprotein as potential delivery nanovehicles.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/cas9-02-01.png” title_text=”cas9-02-01″ _builder_version=”4.16″ _module_preset=”default” width=”73%” custom_margin=”50px||||false|false” border_radii=”on|10px|10px|10px|10px” border_style_all=”dashed” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|desktop” admin_label=”Team” module_id=”team” _builder_version=”4.20.4″ background_color=”#f7f8fc” background_size=”initial” background_position=”center_right” custom_padding=”33px||36px||false|false” custom_padding_tablet=”||150px||false” custom_padding_phone=”||100px||false” top_divider_height=”40%” top_divider_repeat=”0.8x” top_divider_flip=”horizontal|vertical” bottom_divider_height=”30%” bottom_divider_height_tablet=”180px” bottom_divider_height_phone=”110px” bottom_divider_height_last_edited=”on|phone” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#006ef4″ divider_weight=”3px” _builder_version=”4.16″ max_width=”100px” module_alignment=”center” custom_margin=”||0px|” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_margin=”|||” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Team<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/Alexandra-Farcas-001.jpg” title_text=”Alexandra Farcas-001″ align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ width=”50%” custom_margin=”0px||50px||false|false” border_radii=”on|500px|500px|500px|500px” border_width_all=”20px” border_color_all=”rgba(0,59,222,0.14)” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”0px” box_shadow_spread=”20px” box_shadow_color=”rgba(0,59,222,0.06)” global_colors_info=”{}”][\/et_pb_image][et_pb_team_member name=”Dr. Alexandra FARCAS” position=”PhD in Physics” _builder_version=”4.16″ header_font=”|600|||||||” header_font_size=”18px” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” body_line_height=”2em” text_orientation=”center” border_radii_image=”off|0px|0px|0px|0px” border_color_all_image=”rgba(0,59,222,0.06)” border_style_all_image=”none” global_colors_info=”{}”]<\/p>\n

Scientific Researcher
National Institute for Research and Development of Isotopic and Molecular Technologies<\/p>\n

[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/Simion-Astilean.jpg” title_text=”Simion Astilean” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ width=”50%” custom_margin=”||50px|” border_radii=”on|500px|500px|500px|500px” border_width_all=”20px” border_color_all=”rgba(0,59,222,0.14)” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”0px” box_shadow_spread=”20px” box_shadow_color=”rgba(0,59,222,0.06)” locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_team_member name=”Prof. Dr. Simion ASTILEAN” position=” ” use_icon_font_size=”on” _builder_version=”4.16″ header_font=”|600|||||||” header_font_size=”18px” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” body_line_height=”2em” text_orientation=”center” border_radii_image=”on|500px|500px|500px|500px” border_color_all_image=”rgba(0,59,222,0.06)” locked=”off” global_colors_info=”{}”]<\/p>\n

Department of Biomolecular Physics Faculty of Physics,
Babes-Bolyai University
Head of NanoBioPhotonics and
Laser Microspectroscopy Center<\/p>\n

[\/et_pb_team_member][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Contact” module_id=”equipment” _builder_version=”4.20.4″ background_color=”#0c71c3″ use_background_color_gradient=”on” background_color_gradient_stops=”#0c71c3 0%|rgba(1,39,128,0) 60%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#0c71c3″ background_color_gradient_end=”rgba(1,39,128,0)” background_color_gradient_end_position=”60%” background_image=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/insurance-01.png” background_size=”initial” custom_padding=”54px|0px|24px|0px|false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_margin=”|||” custom_margin_last_edited=”off|desktop” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Equipment<\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ make_equal=”on” _builder_version=”4.16″ width=”100%” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”20px|10px|20px|10px|false|false” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/workstation-82.png” title_text=”workstation 82″ align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Workstation Supermicro SYS-7039A-i” content_max_width=”1100px” _builder_version=”4.16″ header_font=”||||||||” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” animation_style=”zoom” animation_intensity_zoom=”10%” animation=”off” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}”]<\/p>\n

Processor 2 x Intel Xeon 4210 10 Core\/20 Core HT, 2.2GHz
RAM 64GB DDR4, 2933 MHz, ECC
Storage 1 x SSD 240GB SATA 6Gb\/s, 1 x HDD 2TB SATA 6 Gb\/s
GPU 2 x GeForce RTX 2080 Ti, 11GB GDDR6<\/p>\n

1 workstation acquired through the project<\/strong><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”10px|10px|10px|10px|false|false” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/workstation-82.png” title_text=”workstation 82″ align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Workstation Supermicro SYS-7039A-i” content_max_width=”1100px” _builder_version=”4.16″ header_font=”||||||||” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” animation_style=”zoom” animation_intensity_zoom=”10%” animation=”off” border_radii=”on|10px|10px|10px|10px” locked=”off” global_colors_info=”{}”]<\/p>\n

Processor 2 x Intel Xeon 4210 10 Core\/20 Core HT, 2.2GHz
RAM 64GB DDR4, 2933 MHz, ECC
Storage 1 x SSD 240GB SATA 6Gb\/s, 1 x HDD 2TB SATA 6 Gb\/s
GPU 2 x GeForce RTX 2080 Ti, 11GB GDDR6<\/p>\n

1 workstation acquired through the project<\/strong><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”10px|10px|10px|10px|false|false” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/storage-82.png” title_text=”storage 82″ align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Network Attached Storage, NAS DS420j” content_max_width=”1100px” _builder_version=”4.16″ header_font=”||||||||” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” animation_style=”zoom” animation_intensity_zoom=”10%” animation=”off” border_radii=”on|10px|10px|10px|10px” locked=”off” global_colors_info=”{}”]<\/p>\n

NAS DS420j CPU Quad-core 1.4GHz, RAM 1 GB DDR4
CAPACITY 16 TB (2 x HDD 8TB), Max 64 TB (16 TB HDD x 4)
CONECTIVITY: USB 3.0 LAN 1GbE
RAID: RAID 0, 1, 5, 6, 10, JBOD<\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ background_color=”#ffffff” custom_padding=”10px|10px|10px|10px|false|false” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-content\/uploads\/2023\/05\/workstation-82.png” title_text=”workstation 82″ align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.16″ locked=”off” global_colors_info=”{}”][\/et_pb_image][et_pb_blurb title=”Workstation SUPERMICRO SYS-7049GP-TRT” content_max_width=”1100px” _builder_version=”4.16″ header_font=”||||||||” header_line_height=”1.6em” body_font=”Montserrat|300|||||||” animation_style=”zoom” animation_intensity_zoom=”10%” animation=”off” border_radii=”on|10px|10px|10px|10px” locked=”off” global_colors_info=”{}”]<\/p>\n

Processor 2 x Xeon Silver 4210 2P 10C\/20T 2.2GHz, Cache 13.75M, 9.6GT 85W
RAM 64GB DDR4, 2933 MHz, ECC
Storage 1 x SSD 240GB SATA 6Gb\/s, 1 x HDD 2TB SATA 6 Gb\/s
4U Rackmountable \/ Tower
GPU 1 x GeForce RTX 3070TI 8GB VRAM, DDR6
GPU 1 x GeForce RTX 3080TI 10GB VRAM, DDR6<\/p>\n

1 workstation acquired through the project<\/strong><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Contact” module_id=”results” _builder_version=”4.16″ background_color=”#0c71c3″ use_background_color_gradient=”on” background_color_gradient_stops=”#073e7a 0%|#082c49 60%” background_color_gradient_overlays_image=”on” background_color_gradient_start=”#073e7a” background_color_gradient_end=”#082c49″ background_color_gradient_end_position=”60%” background_enable_image=”off” background_size=”initial” custom_padding=”40px|0px|46px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Montserrat|300|||||||” text_line_height=”2em” header_font=”||||||||” header_2_font=”||||||||” header_2_font_size=”36px” header_2_line_height=”1.4em” text_orientation=”center” background_layout=”dark” header_2_font_size_tablet=”30px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

Results<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ffffff” global_colors_info=”{}”][et_pb_button button_url=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/results” button_text=”Reports” button_alignment=”center” _builder_version=”4.20.4″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_border_width=”0px” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ffffff” global_colors_info=”{}”][et_pb_button button_url=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/results” button_text=”Papers in ISI indexed journals” button_alignment=”center” _builder_version=”4.20.4″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_border_width=”0px” button_use_icon=”off” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ffffff” global_colors_info=”{}”][et_pb_button button_url=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/results” button_text=”International conferences” button_alignment=”center” _builder_version=”4.20.4″ _module_preset=”default” custom_button=”on” button_border_width=”0px” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” border_radii=”on|10px|10px|10px|10px” border_width_all=”2px” border_color_all=”#ffffff” global_colors_info=”{}”][et_pb_button button_url=”https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/results” button_text=”Workshops” button_alignment=”center” _builder_version=”4.20.4″ _module_preset=”default” custom_button=”on” button_border_width=”0px” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

National Institute for Research and Development of Isotopic and Molecular Technologies (INCDTIM)In silico optimization of CRISPR\/Cas9-Gold nanovehicle designProject financed by UEFISCDI Project Type: Postdoctoral research projects Project Code: PN-III-P1-1.1-PD-2019-0292 Contract No.: PD 37 Project Duration: 01.09.2020 – 31.08.2022Principal Investigator: Dr. Alexandra FARCAS INCDTIM \u2013 National Institute for Research and Development of Isotopic and Molecular Technologies, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":4,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":55,"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/pages\/23\/revisions\/55"}],"wp:attachment":[{"href":"https:\/\/www.itim-cj.ro\/PNCDI\/nanocraud\/wp-json\/wp\/v2\/media?parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}