[et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#8ec545″ background_image=”https:\/\/www.itim-cj.ro\/PNCDI\/pharmexer\/wp-content\/uploads\/2023\/03\/zold2.jpg” min_height=”190px” custom_padding=”40px||22px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”||||||||” text_font_size=”22px” text_orientation=”center” custom_margin=”||||false|false” custom_padding=”67px|||||” global_colors_info=”{}”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” custom_margin=”1px|||||” custom_padding=”8px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”86.1%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”]<\/p>\n
Summary of results:<\/strong><\/span><\/p>\n Environmental pollution is one of the biggest problems that mankind is facing worldwide and a major cause of morbidity and mortality. Water pollution is caused by, among other things, pesticides and herbicides from agricultural practices and pharmaceuticals that end up in water either as a result of drug treatments used by humans or in the livestock industry because they cannot be completely removed in treatment plants.<\/span><\/p>\n In this project we have developed a detection platform integrating nanostructured metal films capable of detecting emerging environmental pollutants by combining optical spectroscopy (Raman) with electrochemistry. The electrochemically-assisted optical detection method is suitable for the simple, rapid, and selective detection of some pharmaceutical pollutants (e.g. propranolol) in relevant media (surface water, drinking water, processed wastewater, etc.). The selective and efficient identification of environmental pollutants demonstrated in this project may have applications in water quality monitoring and thus have a direct positive impact on the quality of life.<\/span><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/www.itim-cj.ro\/PNCDI\/pharmexer\/wp-content\/uploads\/2023\/03\/for-website-results.png” title_text=”for-website-results” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”|0px||||” global_colors_info=”{}”]<\/p>\n The results of the project have been disseminated through presentations at international conferences and the publication of scientific articles in prestigious international journals with impact factors up to 14, such as <\/span>Journal of Pharmaceutical Analysis<\/em>, <\/span>Micromachines<\/em>, <\/span>Sensors<\/em> or <\/span>Microchemical Journal<\/em>. In addition, the project team was co-organizer and host of a workshop dedicated to detection methods on environmental and food safety issues, which was attended by representatives of the political and social environment, such as the Cluj Public Health Directorate, but also of the economic environment and students from universities in Cluj.<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|0px||||” global_colors_info=”{}”]<\/p>\n Results<\/strong>:<\/span><\/span><\/p>\n Simulated optical spectra of plasmonic nanostructures serving as ‘SERS electrodes’. Electrochemical behavior of propranolol. Gold nanostructured films fabricated, characterized and tested as SERS substrates for propranolol detection and analysis. Redox profile of propranolol on unmodified and MIP-modified electrodes. EC-SERS analysis\/ detection of propranolol with portable equipment. EC-SERS analysis\/ detection of propranolol in simulated samples.<\/span><\/p>\n <\/p>\n Articles:<\/span><\/strong><\/p>\n <\/strong>1. R. Chira, J. Fangmeyer, O.I. Neaga, V. Zaharia, U. Karst, E. Bodoki, R. Oprean,\u00a0<\/span>Simulation of the oxidative metabolization pattern of netupitant, a NK1 receptor antagonist by electrochemistry coupled to mass spectrometry<\/i>, Journal of Pharmaceutical Analysis 2021<\/strong>, 11(5), 661-666.\u00a0<\/span><\/span>https:\/\/doi.org\/10.1016\/j. 2. R. Moldovan, V. Toma, B.-C. Iacob, R.I. Stiufiuc, E. Bodoki,\u00a0<\/span>Off-Resonance Gold Nanobone Films at Liquid Interface for SERS Applications<\/i>, Sensors 2022<\/strong>, 22, 236.\u00a0<\/span><\/span>https:\/\/doi.org\/10.3390\/ 3. A. Csapai, D. Toc, F. Popa, N. Tosa, V. Pascalau, C. Costache, A. Botan, C. Popa,\u00a0<\/span>3D Printed Microfluidic Bioreactors Used for the Preferential Growth of Bacterial Biofilms through Dielectrophoresis<\/i>, Micromachines 2022<\/strong>, 13(9), 1377.\u00a0<\/span><\/span>https:\/\/doi.org\/10.3390\/