○ Using the plasma activation-chamber which was designed and built in the first part of the project, we performed a second activation study. We focused on the improvement of the diffusion properties of polymer patches doped with anti-inflammatory substances (designed to be used in the treatment of inflammatory joint problems).
We prepared a set of k-carrageenan polymer sheets, shaped as patches, doped with the following anti-inflammatory compounds: curcumin (polyphenol extract from the root of the plant Curcuma longa) and morin (pentahydroxi-flavone, extracted from plants of the group structure Moraceae).
We studied the amount of the released active substance in the volume of the samples as a function of time, using the transdermal diffusion method. For this, we designed and built in our Institute (INCDTIM Cluj-Napoca), four Franz-type static diffusion cells. We compared the values obtained for cold plasma-treated patches verus standard polymer patches (whose surfaces were not plasma activated). The results of this study will be published in an article entitled:
"Plasma Containing films activated transdermal curcumin and morin in k-carrageenan matrix".
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