Project financed by UEFISCDI: PN III Program - Tinere Echipe de Cercetare
Project Type : Research Projects for Stimulating Creation of Young Research Teams
Project Code: PN-III-P1-1.1-TE-2016-0032
Contract No.: 99/02.05.2018
Project Time Span: 02.10.2015 — 30.04.2020
Principal Investigator: Dr. Lorant Janosi
Antimicrobial peptides are a type of host defense peptides that present both high therapeutic potential and high selectivity of interaction with bacterial cells over mammalian cells. However, the possibility of bacterial resistance occurring against natural AMPs activity, combined with the already picked low-hanging fruits of obvious natural peptide targets, suggests the need for novel AMP design approaches. The main challenge is increasing efficacy of the novel drugs in safety conditions, since previous individual design methods had only limited success thus far.