Proiectul propune dezvoltarea unei formul\u0103ri topice originale, cu ac\u021biune terapeutic\u0103 dubl\u0103, rezultat\u0103 prin \u00eencorporarea de agen\u021bi antiinflamatori \u0219i antiinfec\u021bio\u0219i sintetici (Nimesulid \u0219i Clorhexidin\u0103) \u0219i naturali (extract de Boswellia serrata) \u00een nanovesicule (Bilozomi), NS&CH-Bls@BSE, cu scopul de a \u00eembun\u0103t\u0103\u021bi livrarea compu\u0219ilor activi, optimizarea propriet\u0103\u021bilor biofarmaceutice, asigurarea de rezultate terapeutice eficiente \u00een tratarea afec\u021biunilor inflamatorii ale pielii \u0219i r\u0103nilor infectate, dar reduc\u00e2nd efectele secundare sistemice datorit\u0103 administr\u0103rii transdermice.<\/p>\n\n\n\n
Bilozomii, nanovesicule lipidice \u00eembog\u0103\u021bite cu s\u0103ruri biliare, sunt structure stabile ce favorizeaz\u0103 p\u0103trunderea agen\u021bilor activi prin straturile pielii prin cre\u0219terea permeabilit\u0103\u021bii. At\u00e2t formularea final\u0103, NS&CH-Bls@BSE, c\u00e2t \u0219i componentele acesteia vor fi testate fizico-chimic \u0219i biologic (in vitro<\/em> \u0219i in vivo<\/em>).<\/p>\n\n\n\n Formularea topic\u0103 propus\u0103 va fi realizat\u0103 \u00een colaborare interdisciplinar\u0103 \u00eentre cercet\u0103tori ai institu\u021biei gazd\u0103, Institutul Na\u021bional de Cercetare-Dezvoltare pentru Tehnologii Izotopice \u0219i Moleculare INCDTIM Cluj din Rom\u00e2nia (CO) \u0219i Universitatea de Stat de Medicin\u0103 \u0219i Farmacie \u201eNicolae Testemi\u021banu\u201d din Chi\u0219in\u0103u, Republica Moldova (P), combin\u00e2nd expertiza celor dou\u0103 echipe.<\/p>\n\n\n\n Relevan\u021ba parteneriatului const\u0103 \u00een: dezvoltarea unui produs inovativ prin cercetare comun\u0103; transferul cuno\u0219tin\u021belor dob\u00e2ndite de CO \u0219i accesul cercet\u0103torilor P la infrastructura CO; consolidarea colabor\u0103rilor \u0219i integrarea cercet\u0103torilor P \u00een re\u021belele \u0219tiin\u021bifice din care CO face parte, cre\u0219terea num\u0103rului de propuneri de proiecte comune \u0219i a ratei de succes.<\/p>\n","protected":false},"excerpt":{"rendered":" Proiectul propune dezvoltarea unei formul\u0103ri topice originale, cu ac\u021biune terapeutic\u0103 dubl\u0103, rezultat\u0103 prin \u00eencorporarea de agen\u021bi antiinflamatori \u0219i antiinfec\u021bio\u0219i sintetici (Nimesulid \u0219i Clorhexidin\u0103) \u0219i naturali (extract de Boswellia serrata) \u00een […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-66","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/pages\/66","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/comments?post=66"}],"version-history":[{"count":2,"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/pages\/66\/revisions"}],"predecessor-version":[{"id":68,"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/pages\/66\/revisions\/68"}],"wp:attachment":[{"href":"https:\/\/www.itim-cj.ro\/bilateral\/dual-nano\/wp-json\/wp\/v2\/media?parent=66"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}