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UNITATEA EXECUTIVA PENTRU FINANTAREA INVATAMANTULUI SUPERIOR, A CERCETARII, DEZVOLTARII SI INOVARII (UEFISCDI) |
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Laboratory technology for detection of leukemia biomarkers using new graphene-based materials (BIOLEUK) |
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Project description |
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The major scope of this project is to develop and validate a laboratory technology for the detection of two leukemia biomarkers: 8-hydroxy-2’-deoxyguanosine and 8-nitroguanine, in blood and urine samples.
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A demonstrative model of stochastic sensor, which can provide improved services in the area of public health will be designed, implemented and tested. Other important achievements of the project will be:
(i) cost-efficient and reproducible graphene synthesis (ii) full characterization of graphene properties, as sensing layer on different substrates (iii) studies of detection mechanisms and effect of graphene surface modifications
This will enable to develop sensors with ultra-low detection limits for biomarkers relevant to human health, in laboratory conditions. In this way, we will use the knowledge generated by basic research in the sensor area, for developing a higher level of technological maturity. Stochastic sensing creates a totally new approach, allowing the same systems to be used in vitro and in vivo. Market size: vast applicability in biomarkers, metabolomics, proteomics, genomics.
Two major objectives are proposed: O2: Increase the capacity of the two Research Institutes to generate new lab technologies and to provide them to economic agent
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