Results
Resulting summary
Two new dopamine analogues have been obtained, 2-aminomethyl-3-(3,4-dihydroxyphenyl)propionamide and 3,4-dihydroxybenzylidenehydrazine.
These were polymerised under conditions similar to polydopamine, both in bulk and on surfaces. For the bulk polymers their structure, respectively the monomeric units constituting the polymer structure, were proven by specific structural analysis methods such as solid-state NMR, FTIR or MS.
The new monomers/polymers obtained have the ability to adhere to surfaces such as glass, TiO2 nanoparticles or magnetic nanoparticles, which was demonstrated by AFM, zeta potential, thermogravimetric analysis, XPS and electron microscopy.
The optical behaviour of the polymers as well as TiO2 or magnetite nanoparticles was demonstrated by UV-Vis and fluorescence both in solution and by confocal fluorescence microscopy. For magnetic nanoclusters obtained by solvothermal reaction, the biocompatibility was studied on 3 types of cells, HUVEC, A375 and fibroblasts. The clusters are internalized in all these cells, showing fluorescence depending on the combination of cluster type/cell type. This gives them potential applications in theranostics, for simultaneous fluorescence bioimaging/MRI treatments and and/or hyperthermia.
Articles
Poly-3,4-Dihydroxybenzylidenhydrazine, a Different Analogue of Polydopamine – Natalia Terenti, Alexandra Falamas, Diana Bogdan, Claudiu Filip, Adriana Vulcu and Anca Petran, Nanotechnol Rev, 2024, in print
One-pot synthesis and biological assessment of fluorescent magnetite clusters coated with polydopamine and –analogues – Anca Petran, Maria Suciu, Ioana Baldea, Sanda Boca, Ovidiu Pana, Cristian Leoștean, Monica Dan, Alexander Bunge – Journal of Materials Chemistry B, submitted
Poly-2-aminomethyl-3-(3,4-dihydroxyphenyl)propionamide, from structure to proprieties – Anca Petran, Andreea Petronela Crişan, Claudia Lar, Adriana Popa, Teodora Radu, Alexandra Cioriţă, Diana Bogdan, Mihaela Silion, Claudiu Filip – ACS Appl. Polym. Mater. 2023, 5, 5, 3370–3380
Conferences
Participation at the 14th International Conference on Physics of Advanced Materials (ICPAM-14) with oral presentation Polydopamine Analogues from Structure to Applications – A. Petran, M.Suciu, T. Radu, J. Liebscher
Participation at the 14th International Conference on Physics of Advanced Materials (ICPAM-14) with poster Surface chemistry of polydopamine and its derivates – T. Radu, A. Petran
Participation at the International Conference on Nanosciences & Nanotechnologies (NN23) with oral presentation Different Perspective of Polydopamine Analogues – A. Petran, T. Radu, A. Bogdan, A. Fălămaș, A. Bunge, C. Lar
Participation at the ANM2023 conference “APM – Advanced Polymer Materials” with oral presentation Polydopamine Analogues from Structure to Properties – A. Petran, M.Suciu, T. Radu, A. Fălămaș, A. Bogdan, I. Baldea
Participation at the 14th PIM 2023 Processes in Isotopes and Molecules with poster Particularities of polydopamine analogues – A. Petran, A. Fălămaș, N. Terenti, C. Lar, A. Cioriţă, C. Filip
Participation at the 14th PIM 2023 Processes in Isotopes and Molecules with poster Solvatochromism effect in new polydopamine analogues – N. Terenti, A. Fălămaș, A. Petran
Participation at the 2nd Polydopamine Symposium with poster Structure and Properties of Poly-2-aminomethyl-3-(3,4-dihydroxyphenyl)propionamide – A. Petran, C. Lar, D. Bogdan, C. Filip
Participation at the 14th International Conference on Physics of Advanced Materials ICPAM, Dubrovnik, Croatia, 8-15th September 2022 with oral presentation ZnO nanoparticles and metal-ZnO nanomaterials as substrates for surface enhanced Raman scattering and surface enhanced fluorescence – presenter A. Fălămaș
Participation at the 14th International Conference on Physics of Advanced Materials ICPAM, Dubrovnik, Croatia, 8-15th September 2022 with oral presentation Polydopamine Analogues from Structure to Properties – presenter A. Petran
Participation at the 14th International Conference on Physics of Advanced Materials ICPAM, Dubrovnik, Croatia, 8-15th September 2022 with poster presentation Surface chemistry of polydopamine and its derivates – presenter T. Radu